"I have to put on the greatest show on Earth in the middle of the greatest show on Earth," the singer says in the episode of "Anderson" to air on CNN Thursday.
It's not just the singing that scares her, but the demands of putting on a spectacle without the usual long lead time to erect the sure-to-be elaborate set.
"I have 8 minutes to set it up, 7 minutes to take it down and 12 minutes to put on the greatest show on earth, OK, that's a lot of pressure," said Madonna.
No hint on whether she'll reprise her greatest hits of the 1980s and 1990s; introduce something new; or even get a surprise appearance from sometime-collaborator Justin Timberlake, whom you may recall joined Janet Jackson and actually assisted in the infamous "wardrobe malfunction" in 2004.
Asked what she'll be doing, she would only offer a coy reply: "I'll be singing."
Madonna follows in the footsteps of Black Eyed Peas, Tommy Petty and The Who, all of whom have rocked the Super Bowl in past years.
The Super Bowl, with the New York Giants vs the New England Patriots, kicks off at 6:30 p.m. ET on NBC.