Four people were injured in a crash on Route 68 and Barnes Road in Wallingford on Sunday evening.
Police received a call at 4:16 p.m. reporting the head-on collision between two cars. One car was going the wrong way, according to police.
Investigators said a man was driving one car and the other vehicle was carrying a man and two children.
All four victims were taken to Yale-New Haven Hospital. The man traveling alone is in serious condition.
The roadway was closed as police investigate the cause of the crash.