Interstate 95 North was closed at exit 32 in Stratford for several hours on Tuesday after a multivehicle crash and a fuel spill.
Officials said around 100 gallons of fuel spilled from saddle tanks in the crash around 2 p.m.
No injuries were reported, but there were significant traffic delays on both sides of the highway through rush hour.
The Department of Energy and Environmental Protection responded to the crash scene to help deal with the fuel spill.
The highway reopened around 5 p.m.