LifeStar transported a 29-year-old Manchester man to Hartford Hospital after him pickup crashed in the Broad Brook area of East Windsor.
Police said Jeffrey Muldoon failed to make a turn while heading westbound on Route 140, went off the road and into the woods, where he hit a tree.
The truck was heavily damaged and Muldoon had to be pulled from the car.
Yosky Road was closed between North and Melrose roads as emergency crews responded, but it has since reopened.
Muldoon was the only person in the car and police said it appears that speed was a factor.
Officers are investigating and ask witnesses to call Officer Tamrah Stepien at 860-292-8240, extension 323.