Interstate 91 South was closed in Wallingford for hours after several cars collided Thursday afternoon.
All southbound lanes between exits 15 and 14 were closed until just past 6 p.m.
State Police report five passenger cars and a commercial vehicle are involved.
Many injuries are reported, at least one person is seriously wounded.
This is the same area of a fatal accident Tuesday afternoon involving a DOT vehicle.
View interactive traffic maps and live cameras at the Traffic & Autos page.
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