Josh Carlton and Jalen Adams each scored 17 points and UConn routed New Hampshire 91-66 on Saturday.
Christian Vital added his first double-double of the season, scoring 14 points and grabbing 10 rebound for the Huskies (5-1).
Jordan Reed had 17 points for New Hampshire (2-4), which has not beaten a Division I program this season.
The Huskies have struggled in recent years with midmajors, losing in 2016 to Wagner and Northeastern and needing overtime last season to beat Columbia and Monmouth.
But they took control of this one from the opening tip.
Carlton dunked on the first possession of the game and UConn never trailed.
A 3-point play from Vital gave the Huskies their first double-digit lead at 18-8. Carlton (4 of 5), Jalen Adams (4-4) and Tyler Polley (5-6) combined to hit 13 of their 15 shots in the first half and UConn went into intermission up 48-29.
A spin move and double-pump layup by Alterique Gilbert made him the fifth UConn player to hit double figures. That highlighted an 11-2 run that put the Huskies up 73-48 and the Huskies led by as many as 28 points in the second half.
New Hampshire: The Wildcats held the Huskies to just 4-of-16 shooting from 3-point range, but made just 8 of 30 from behind the arc. The Wildcats had made 10 or more 3-pointers in each of the first three games and came into this game 50 of 130 from long range.
UConn: The Huskies had five players in double figures. Polley finished with 12 points and Gilbert had 11. UConn dominated underneath, outscoring the Wildcats 54-24 in the paint and outrebounding UNH 50-33.
New Hampshire: The Wildcats host Boston University on Wednesday night.
UConn: The Huskies return to campus to play their third of five straight home games on Tuesday against UMass Lowell.