Freshman Andre Drummond scored a season-high 24 points and grabbed eight rebounds as Connecticut extended its home winning streak to 40 games against non-conference opponents.
Alex Oriakhi added 15 points and Shabazz Napier had 13 assists for UConn (9-1), which is 117-4 under Jim Calhoun in home games against non-conference opponents from New England, including 114 wins in the last 115 such games.
R.J. Evans had 15 points for the Crusaders (4-7).
The Huskies committed just one foul in the first half and finished with eight.
UConn used an 18-0 run to pull away to a 43-24 halftime lead.