A two-alarm blaze broke out early Thursday morning at the Longley Building on the UConn Depot campus in Storrs.
Fire departments provided mutual aid from Mansfield, Tolland, North Coventry, Columbia, Coventry, Willington and Ashford.
No one was inside the building at the time of the fire and no one was injured, according to UConn officials.
The Longley Building, which is located on Middle Turnpike, houses several labs and facilities, as well as The Center for Transportation and Livable Systems.
UConn officials said the fire will have no impact on classes today.
The extent of the damage has not been determined and the cause of the fire is under investigation.