Interstate 95 North was closed for around seven hours on the West Haven-New Haven line since 3:15 a.m. on Tuesday.
Two lanes reopened around 10 a.m.
State police said a tractor-trailer carrying orange juice jackknifed around 3:15 a.m. between exits 45 and 46 and all lanes closed.
There was also a fuel leak and a light pole was knocked down.
Crews from Consumer Protection, the state Department of Energy and Environmental Protection and Department of Transportation were called.
No injuries were reported.
The accident was fully cleared just after 5 p.m.