Route 83 in Vernon has reopened after a serious crash closed it for hours on Friday afternoon.
Police said the crash happened at Route 83 and Hockanum Boulevard shortly before 3 p.m.
Officers said one driver, an adult male, was taken by ambulance to Hartford Hospital with life-threatening injuries. A second driver, an adult female, was taken to Manchester Hospital with non life-threatening injuries.
Route 83 was closed between Dobson Road and Merline Road and there were major traffic delays. The road has since reopened.
A reconstruction team responded to the scene to perform skid tests and take measurements.
This is the second crash on Route 83 this week resulting in serious injuries, police said.