Part of Route 6 was closed in Farmington after a crash on Wednesday afternoon.
Police said the road was closed between Fienemann Road and Route 10 near the Exxon gas station.
The crash involved a pickup truck and a minivan.
Five people were taken to the hospital, including three children, police said. The children were in the minivan.
All of the injuries appeared non-life threatening, according to police.
Route 6 reopened around 4:30 p.m.