The Huskies (4-0) were playing their first road game of the season and overwhelmed the Cougars (2-2) both inside and outside, making 12 of 23 3-pointers and outrebounding BYU 46-27.
Renee Montgomery was 5-for-6 from beyond the arc and led the Huskies with 19 points. Tina Charles added 13 points and Kalana Green scored 11 for UConn, which did not appear the least bit distracted by Sunday's upcoming game against No. 4 Oklahoma.
The Huskies should be fresh for the Sooners after pulling their starters midway through the second half on Tuesday.
Connecticut shot 60 percent, going 19-for-28 in the second half. Lorin Dixon added 11 points and Kaili McLaren scored 10 as six Huskies scored in double figures.
Mindy Nielson led BYU with 14 points.
After leading 47-29 at halftime, UConn opened the second half 5-for-5 from the floor, including two 3-pointers by Moore. The second put UConn up 59-34 and forced BYU to call a time out to try and cool off the Huskies.
It didn't work.
UConn made its next six, too, then finally missed a shot when Dixon's layup attempt hit off the rim with about 12:45 left in the game and UConn up 73-36. Greene came right back with a short jumper and the Huskies were up 75-36 and the rout continued behind the Huskies' reserves.
For BYU, it wasn't quite as bad as when the Cougars faced the Huskies a year ago. Connecticut opened that game with a 23-0 run and won it 80-34.
BYU kept it close early this time, tying it at 7-7 on Mindy Nielson's layup before the Huskies took off on a 10-2 run and led the rest of the way.
Jazmine Foreman and Nielson hit back-to-back 3-pointers to get the Cougars within 36-23 late in the first half, then UConn pulled away with an 11-3 run. Greene and Moore took steals in for uncontested layups, Montgomery added her fourth 3-pointer of the half and then Dixon managed to get an underhanded layup through traffic to go in to put the Huskies up 47-26.
Nielson banked in a 3-pointer at the buzzer to get BYU within 47-29 at halftime.