Smith said her last "Mornings with Ray and Diane" show will be on Wednesday, Dec. 31.
"I understand the difficult financial decisions ... being made by owners of radio stations throughout the country," Smith said In an e-mail sent to the media.
A decade ago, Smith left the anchor desk at WTNH and became a morning talk personality, where she was teamed with Ray Dunaway.
She has continued her "Positively Connecticut" series on public broadcasting and is planning to host a new weekly show next year. She indicated that station management was "exploring" ways she could still contribute to the station.
McEnroe, a columnist with the Hartford Courant, has not commented publicly on his departure from WTIC.
The radio station, in a news release, said that "Sound Off Connecticut," hosted by Jim Vicevich, would expand and run from 9 a.m. to noon. And in place of McEnroe, Aaron Kupec and Bill Pearse would anchor a new afternoon news block.
"We believe increasing our live news coverage and providing listeners with more ways to interact with the station is the right direction for WTIC to be moving as we all look for ways to better adapt to the changing business environment," Operations Manager Steve Salhany said.
The changes go into effect Monday, Jan. 5.