A 60-year-old Haddam woman was killed in a crash on Thursday morning on Killingworth Road in Haddam.
Debra Campagna drifted while driving on Route 81, crossed into the southbound land and struck another driver, head-on, police said.
Campagna was taken by Lifestar helicopter to Hartford Hospital with a fatal injury.
The other driver, a 62-year-old Haddam woman, sustained serious injuries and was taken to Hartford Hospital, police said.
The road was wet at the time of the crash, police said.