Interstate 95 Southbound was closed in Westbrook for hours between exits 65 and 64 because a box truck carrying cheese overturned, but the road has since reopened.
The driver of the truck was conscious and alert, state police said.
There is some residual traffic, but it is moving smoothly.
To get around the crash scene, take Route 153 South to Route 1.
A crash on I-95 South in Milford between exits 38 and 32 has since cleared.