Napheesa Collier scored 22 points and Katie Lou Samuelson added 21 to lead No. 3 UConn to a 79-39 rout of SMU, the Huskies' 107th straight victory over an American Athletic Conference opponent.
Christyn Williams had 12 points and Megan Walker chipped in with 11 for the Huskies (17-1, 6-0). UConn has won every AAC game in both the regular season and conference tournament since the league was formed in 2013.
Alicia Froling had 13 points and Johnasia Cash scored 12 for SMU (7-12, 1-5), which has lost seven of eight.
UConn put on clinic in ball sharing, with 26 assists on 31 baskets.
The Mustangs led 7-6 before layups by Collier and Samuelson started a 12-0 UConn run.
The Huskies went to a full-court press on defense, led 24-10 after one quarter and were in control the rest of the game. They had 11 of their 16 steals in the first half and SMU turned the ball over 16 times before the break.
The Mustangs scored just six points in the second quarter and UConn led 46-16 after a 3-pointer from Megan Walker just before the halftime buzzer.
The Huskies turned down the pressure in the second half but forced 24 turnovers in the game while giving up the ball just six times.
SMU: The roster includes seven freshmen but they accounted for just nine points, led by Marie Olson's five.
UConn: Collier is approaching some big career milestones. The senior needs 11 rebounds to reach 1,000 and 60 points to get to 2,000.
SMU: The Mustangs return home to face South Florida on Saturday
UConn: The Huskies host UCF at the XL Center in Hartford on Sunday.