Interstate 395 South was closed through Friday morning in Waterford because of a crash involving a commercial vehicle, according to state police.
Troopers said they were called to the area of exit 2 to investigate a two-car accident at about 6 p.m.
The southbound side of the highway was shut down and a lane of traffic is closed on I-395 North. Police said a crane truck lost its tire, causing the crash.
By Friday at 6:30 a.m., CT DOT reported that lanes were beginning to reopen as emergency maintenance work cleared up the scene.
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Drivers were being advised to take alternate routes and expect heavy delays during the maintenance.
No injuries were reported.